The First Clinical Trial to Support (a certain type of) Vitamin D Therapy For Covid-19

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virusIn an article posted by Shin Jie Yong it was reported that two similar groups were given the best medical treatment known at the time for Covid 19. One group was given in addition Oral Calcidediol while the control group was not:

The study does admit the only difference between the 2 test groups is that the control group had a higher prevalence of hypertension than the calcifediol group (57.69% vs. 24.19%).

What the study did and found

Researchers randomly allocated 76 confirmed cases of Covid-19 into either oral calcifediol (50 patients) or no-calcifediol control (26 patients) groups on the day of the hospital admission. Oral calcifediol was given at high doses at 0.532 mg on the first day and then at 0.266 mg on the third and seventh day, and then weekly until discharge or admission to the intensive care unit (ICU). Calcifediol, also called 25-hydroxyvitamin D3, is the main metabolite (effector) of vitamin D3.

Results revealed that 13 out of 26 patients (50%) in the control group were admitted to ICU, and two died in the end. In the calcifediol group, only one out of 50 (2%) required ICU admission, and none died. These results were statistically significant, equating to a 93% reduction in odds of ICU admission after adjusting for possible confounders (e.g., hypertension).

“Our pilot study demonstrated that administration of a high dose of calcifediol…significantly reduced the need for ICU treatment of patients requiring hospitalization due to proven Covid-19,” the study authors concluded. “Calcifediol seems to be able to reduce the severity of the disease, but larger trials with groups properly matched will be required to show a definitive answer.”

2. Why calcifediol over native vitamin D3?

Calcifediol is the actual hormonal effector of vitamin D3. Upon contact with sun rays (UV-B spectrum), the skin makes vitamin D3, which can also be taken as a supplement. The liver then converts vitamin D3 into 25-hydroxyvitamin D3, also called calcifediol or calcidiol that has wide-ranging effects on the immune system and other physiological systems. In this sense, calcifediol is a better biomarker for the body’s stores of vitamin D3.

Calcifediol is also 3.2-fold more effective than native vitamin D3 supplements in restoring low blood levels of vitamin D3. Because normal vitamin D3 needs to undergo liver processing first, which is not required for calcifediol. Another perk of calcifediol is its higher intestinal absorption rate.

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