As of February 2021, 66 vaccine candidates are in clinical research, including 17 in Phase I trials, 23 in Phase I–II trials, 6 in Phase II trials, and 20 in Phase III trials. Trials for four other candidates were terminated. In Phase III trials, several COVID‑19 vaccines demonstrate efficacy as high as 95% in preventing symptomatic COVID‑19 infections. As of February 2021, ten vaccines are authorized by at least one national regulatory authority for public use: two RNA vaccines (the Pfizer–BioNTech vaccine and the Moderna vaccine), three conventional inactivated vaccines (BBIBP-CorV, Covaxin, and CoronaVac), four viral vector vaccines (Sputnik V, the Oxford–AstraZeneca vaccine, Convidicea, and the Johnson & Johnson vaccine), and one peptide vaccine (EpiVacCorona).
According to https://theconversation.com/from-adenoviruses-to-rna-the-pros-and-cons-of-different-covid-vaccine-technologies-145454 The World Health Organisation lists about 180 COVID-19 vaccines being developed around the world.
That site reports:
Each vaccine aims to use a slightly different approach to prepare your immune system to recognise and fight SARS-CoV-2, the virus that causes COVID-19.
However, we can group these technologies into five main types. Some technology is tried and trusted. Some technology has never before been used in a commercial vaccine for humans.
The Pfizer Vaccine is Based on new technology manipulating a person’s RNA.
There is insufficient testing to know the long-term impact on the body in several years time.
The above mentioned web site mentions some but by no means all of the downsides of the RNA Vaccines
- there are no approved DNA/RNA vaccines for medical use in humans, hence their alternative name: next-generation vaccines. So they are likely to face considerable regulatory hurdles before being approved for use
- as they only allow a fragment of the virus to be made, they may prompt a poor protective immune response, meaning multiple boosters may be needed
- there’s a theoretical probability vaccine DNA can integrate into your genome.
Here are some of the Alternatives to RNA Vaccines
2. Virus vectors
These vaccines use a virus, often weakened and incapable of causing disease itself, to deliver a virus antigen into the body. The virus’ ability to infect cells, express large amount of antigen and in turn trigger a strong immune response make these vaccines promising.
- highly specific delivery of antigens to target cells and high expression of antigen after vaccination
- often a single dose is enough to stimulate long-term protection.
Inactivated vaccines are a tried and trusted method of vaccination. It’s the technology used in the vaccine against poliovirus and in some types of flu vaccines. Inactivated vaccines contain viruses treated with heat, chemicals, or radiation so they cannot replicate, but can still trigger an immune response.
- a known technology, generally considered safe
- can be used in people with weakened immune systems.
4. Live-attenuated virus
Live-attenuated vaccines are among the most successful existing vaccine strategies, already used to protect against measles and polio. These contain virus weakened in the lab. The virus is still viable (live) but cannot cause disease. After vaccination, the viruses in these vaccines grow and replicate, stimulating an excellent immune response.
- strong protection as vaccine mimics the natural infection process
- cost effective for large-scale manufacturing with a familiar regulatory approval pathway
- single immunisation without needing extra molecules (adjuvants) to stimulate the immune system.
5. Protein subunit
Subunit vaccines do not contain live components of the virus, but are made from purified pieces of the virus (protein antigens) that trigger an immune response. Again, this is an existing technology, used for instance in hepatitis B vaccines.
- with no live components, subunit vaccines are generally thought to be safe
- can be used in people with weakened immune systems and other vulnerable populations.
There are also drawbacks to the alternatives to Pfizer and benefits to the Pfizer vaccine. You can read more in the article I quoted from at https://theconversation.com/from-adenoviruses-to-rna-the-pros-and-cons-of-different-covid-vaccine-technologies-145454
Other Drawbacks of the RNA Solution
- Experimental mRNA vaccines cause 600 new cases of eye disorders and leave 5 people blind, according to UK Government
- Covid-19 RNA based Vaccine and the Risk of Prion Disease
I am upset that the Israeli Ministry of Health is pushing only one solution, namely, the Pfizer solution, spending taxpayer money to pay for government sponsored advertising and using various pressures on Schools and Businesses to force or entice the public to use specifically the poorly tested Pfizer/RNA solution.
This in addition to the possibility that Ivermectin might be a better solution than all the vaccines.